[Comment] The genetic architecture of dementia with Lewy bodies is shaping up

Genome-wide association studies (GWAS) have made substantial contributions to our understanding of complex neurodegenerative diseases. For example, the largest GWAS of Alzheimer's disease so far has identified 19 loci in addition to APOE and revealed key pathways of disease pathogenesis, including inflammation and immune response, lipid metabolism, and endocytosis.1 Similarly, two GWAS of Parkinson's disease have uncovered 41 loci and suggested a major role of autophagy and lysosomal biology in Parkinson's disease risk.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research