Association analysis of SLC6A4 and HTR2A genes with obsessive-compulsive disorder: influence of the STin2 polymorphism

Obsessive-Compulsive Disorder (OCD) is a complex and chronic disorder characterized by recurrent thoughts and/or repetitive behaviors. Given the potent anti-obsessional effects of the so-called serotonin reuptake inhibitors, genes related to serotonergic system may be well implicated in the etiopathogenesis of OCD. The gene encoding the serotonin transporter (SLC6A4), which shows a variable number of tandem repeat (VNTR) polymorphism in intron 2 (STin2), have been previously associated with OCD.

Source: Comprehensive Psychiatry - December 15, 2017 Category: Psychiatry Authors: Chayenne Karine Ferreira Gomes, Tamiris Vieira-Fonseca, Fernanda Brito Melo-Felippe, Juliana Braga de Salles Andrade, Leonardo F. Fontenelle, Fabiana Barzotti Kohlrausch Source Type: research