Role of RNA Modifications in Brain and Behavior

We present evidence for the existence of an “RNA code”, similar to the histone code, that fine‐tunes gene expression in the nervous system by using combinations of different RNA modifications. Unlike the relatively stable genetic code, this combinatorial RNA epigenetic code, or epitranscriptome, may be dynamically reprogrammed as a cause or consequence of psychiatric disorders. We discuss potential mechanisms linking disregulation of the epitranscriptome with brain disorders and identify potential new avenues of research.
Source: Genes, Brain and Behavior - Category: Genetics & Stem Cells Authors: Tags: REVIEW Source Type: research