Zebrafish Rfx4 controls dorsal and ventral midline formation in the neural tube

Conclusions: The midline patterning functions of rfx4 are conserved, since rfx4 regulates transcription of foxa2 and zic2 in zebrafish and in mouse. In contrast, zebrafish rfx4 function is dispensable for forebrain morphogenesis, while mouse rfx4 is required for normal formation of forebrain ventricles in a ciliogenesis‐dependent manner. Collectively, this report identifies conserved aspects of rfx4 function and establishes a robust new genetic model for in‐depth dissection of these mechanisms. This article is protected by copyright. All rights reserved.

Source: Developmental Dynamics - December 1, 2017 Category: Molecular Biology Authors: Irina Sedykh, Abigail N. Keller, Baul Yoon, Laura Roberson, Oleg V. Moskvin, Yevgenya Grinblat Tags: Patterns & Phenotypes Source Type: research