Editorial Commentary: Obesity and Heart Failure with Preserved Ejection Fraction: A Single Disease or Two Co-Existing Conditions?

Heart failure ( HF) with preserved ejection fraction (HFpEF) is characterized by the presence of multiple comorbidities. In this issue of the Journal, Prenner and Mather [1] reviewed the literature related to the role of obesity in the development and progression of HFpEF. They describe how obesity increases the risk for HFpEF, potentially as the result of excess fat mass (FM) responsible for hemodynamics and cardiac structural changes[2,3], and for the production of proinflammatory cytokines (i.e., adipokines), with cardiodepressant properties.

Source: Trends in Cardiovascular Medicine - December 14, 2017 Category: Cardiology Authors: Salvatore Carbone, Ambarish Pandey, Carl J. Lavie Source Type: research