Carney Complex: Eleven Open Heart Operations in a Single Family.

Carney Complex: Eleven Open Heart Operations in a Single Family. Korean J Thorac Cardiovasc Surg. 2017 Dec;50(6):471-473 Authors: Han SJ, Han W, Kang MW, Yu JH, Kang S, Na MH Abstract Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genomic loci, including the protein kinase A regulatory subunit 1 gene. The results revealed no specific mutations, except for a common single nucleotide polymorphism. This case series of Carney complex emphasizes the importance of close longitudinal follow-up because of the high rate of tumor recurrence irrespective of the site. Clinicians should not overlook the specific features of familial myxoma. PMID: 29234618 [PubMed]
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research