Understanding pluripotency under Folic acid deficiency using embryonic stem cells as an in vitro model

Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst them, the one which is gaining importance in the recent past is the metabolism of stem cells, especially One carbon metabolism. Being associated directly or indirectly, with DNA and Histone methylation, One carbon metabolism has an important role to play as far as epigenetic regulation of stemness is concerned. Folic acid being a methyl donor forms an important component of One Carbon metabolism, and thus its availability has a significant effect on the methylation reactions.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research