Neuropsychiatric disorders: Stressful depression

Nature Reviews Neuroscience 19, 3 (2018).
doi:10.1038/nrn.2017.153

Author: Sian Lewis
Major depessive disorder (MDD) is linked to increased levels of circulating pro-inflammatory cytokines, such as interleukin 6 (IL-6). Among mice subjected to chronic social defeat stress (a rodent model of depression), the expression of the tight junction protein claudin-5 (CLDN5) at the blood–brain barrier (BBB)

Source: Nature Reviews Neuroscience - December 7, 2017 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research