Neurodegenerative disease: Remodelling neurodegeneration

Nature Reviews Neuroscience 19, 3 (2018).
doi:10.1038/nrn.2017.152

Author: Sian Lewis
TAR DNA-binding protein 43 (TDP43) is implicated in amyotrophic lateral sclerosis (ALS) and in some cases of frontotemporal dementia (FTD). Here, in a fly model of ALS–FTD, TDP43 reduced the recruitment of chromodomain-helicase-DNA-binding protein 1 (Chd1), a chromatin remodelling protein, to neuroprotective stress genes, resulting

Source: Nature Reviews Neuroscience - December 7, 2017 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research