Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment.

Chronic kidney disease (CKD) is an increasing global health burden. Disturbance in purine metabolism pathway and a higher level of serum uric acid, called hyperuricemia, is a risk factor of CKD, and it has been linked to increased prevalence and progression of the disease. In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE.

Source: Medical Hypotheses - December 13, 2017 Category: Biomedical Science Authors: Muhammed Khairujjaman Mazumder, Banashree Chetia Phukan, Aradhana Bhattacharjee, Anupom Borah Source Type: research