A Novel Amiodarone-Eluting Biological Glue for Reducing Postoperative Atrial Fibrillation: First Animal Trial

Conclusions:
Local alginate-based amiodarone delivery demonstrated an RAR frequency reduction of clinical importance in response to burst pacing. The electrophysiological response was achieved while maintaining below-detection systemic drug levels. Current findings may point to the system’s future applicability in reducing POAF risk in humans.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2014 Category: Cardiology Authors: Beckerman, Z., Azran, A., Cohen, O., Nir, R.-R., Maessen, J. G., Bianco-Peled, H., Bolotin, G. Tags: Experimental Studies Source Type: research