Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an APOC3 Founder Mutation [Original Articles]

Conclusions— APOC3/APOA5 constitutes a major locus for serum triglycerides in Amerindians, especially the Pimas, and these results provide an empirical example for the concept that population-based linkage analysis is a useful strategy to identify complex trait variants.

http://circgenetics.ahajournals.org/cgi/content/short/10/6/e001809?rss=1

Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Hsueh, W.-C., Nair, A. K., Kobes, S., Chen, P., Goring, H. H. H., Pollin, T. I., Malhotra, A., Knowler, W. C., Baier, L. J., Hanson, R. L. Tags: Lipids and Cholesterol, Genetic, Association Studies, Genetics Original Articles Source Type: research