Asymmetric Synthesis of 2H ‐Azirines with a Tetrasubstituted Stereocenter by Enantioselective Ring Contraction of Isoxazoles

AngewchemAsymmetric Synthesis of 2H ‐Azirines with a Tetrasubstituted Stereocenter by Enantioselective Ring Contraction of Isoxazoles: Highly strained 2H ‐azirines with a tetrasubstituted stereocenter were synthesized by the enantioselective isomerization of isoxazoles with a chiral diene–rhodium catalyst system. The effect of ligands...

Source: Organometallic Current - December 13, 2017 Category: Chemistry Tags: Asymmetric Rh Catalyzed Ring contraction Source Type: blogs