Mutations of the Glycine Cleavage System Genes Possibly Affect the Negative Symptoms of Schizophrenia through Metabolomic Profile Changes

ConclusionsThese results suggest that GCS rare variants possibly contribute to the pathophysiology of SCZ by affecting the negative symptoms through elevation of aspartate.

Source: Psychiatry and Clinical Neurosciences - December 12, 2017 Category: Neuroscience Authors: Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, Masaki Nishioka, Atsuhiko Takaya, Mamoru Tochigi, Yoshiya Kawamura, Tadashi Umekage, Kayoko Kato, Tsukasa Sasaki, Yoshiaki Ohashi, Kazuya Iwamoto, Kiyoto Kasai, Chihiro Kakiuchi Tags: Regular Article Source Type: research