Improved Insulin Sensitivity Appears to Remain for a Mean of Four Years Following Islet Cell Transplant for Type 1 Diabetes

ConclusionsIS measured by SIis was improved several years following transplant, while IS measured by HOMA‐IR did not worsen. Higher exenatide dose, more islets transplanted, and diet and exercise (lowering leptin and RANKL) may improve IS, which may enhance glycemic control and lower metabolic demand on transplanted islets. Long‐term clamp studies are needed to confirm these results.

Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Brett Rydzon, Rebecca S. Monson, Jose Oberholzer, Krista A. Varady, Melena D. Bellin, Kirstie K. Danielson Tags: RESEARCH ARTICLE Source Type: research