RNA ‐sequencing study of peripheral blood mononuclear cells in sporadic Ménière's disease patients: possible contribution of immunologic dysfunction to the development of this disorder

In conclusion, our study first offers a new perspective in MD development on the basis of RNA expression patterns, suggesting that immune factors might be involved in the MD pathogenesis. Remarkably, GSTM1 might be a possible candidate gene for the diagnostic biomarker of MD and provides the basis for further biological and functional investigations. We first use RNA‐seq technology to characterize and identify differentially expressed genes in MD. Biological information analyses suggest that immune factors might be involved in the development of MD. GSTM1, is probably a candidate for the diagnostic biomarkers of MD and provides the basis for further investigations.
Source: Clinical and Experimental Immunology - Category: Allergy & Immunology Authors: Tags: Original Article Source Type: research