Zn-ProPhenol Catalyzed Enantio- and Diastereoselective Direct Vinylogous Mannich Reactions between α,β- and β,γ-Butenolides and Aldimines

We report a Zn-ProPhenol catalyzed reaction between butenolides and imines to obtain tetrasubstituted vinylogous Mannich products in good yield and diastereoselectivity with excellent enantioselectivity (97 to>99.5%ee). Notably, both α,β- and β,γ-butenolides can be utilized as nucleophiles in this transformation.

Source: Organometallic Current - December 11, 2017 Category: Chemistry Tags: Enantioselective Mannich Reaction Zn Catalyzed Source Type: blogs