Ni –Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne

JacsNi –Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne: A Ni –Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes has been developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strat egy for the C–C bond cleavage of unreactive cyclopropanes.

Source: Organometallic Current - December 11, 2017 Category: Chemistry Tags: Cycloaddition Enantioselective Ni Catalyzed Source Type: blogs