Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C –H Functionalization

This report describes a catalyst-controlled regio- and diastereoselective synthesis ofN-unprotected pyrrolidines via dirhodium catalyzed intramolecular nitrene insertion into sp3 C –H bonds. The reaction proceeds at rt without external oxidants, nitrene stabilizing groups, or directing functionality.

Source: Organometallic Current - December 11, 2017 Category: Chemistry Tags: C-H Functionalization Diastereoselective Rh Catalyzed Source Type: blogs