Targeting TYMP for cardiovascular disease: How far are we?

The metabolism of nucleic acids, such as DNA and RNA, involves their synthesis and degradation through chemical modifications of their constitutive units, the nucleotides. Nucleotide synthesis generally involves chemical reactions that add a phosphate, pentose sugar, and a nitrogenous base or nucleobase, while their degradation may involve the disassembly of the nucleotide to recycle its parts, or its modification to be transformed into another molecule. Both synthesis and degradation require separate enzymes to perform the chemical reactions, and each enzyme may have very restricted targets and operate in specific cell types throughout the body.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research