Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study

Conclusion To the best of our knowledge, this study is the first report on reduced expression of CASP8 in breast cancer versus adjacent normal tissues. Our data support previous results obtained from cell lines and therefore highlights the seminal role of the induction of CASP8 expression, as a novel therapeutic approach, in order to sensitize tumour cells to apoptotic stimuli.
Source: Journal of the Egyptian National Cancer Institute - Category: Cancer & Oncology Source Type: research