Reconstruction after salvage laryngectomy

Over the past few decades, the treatment paradigm of laryngeal cancer has shifted away from upfront surgery and towards organ-preserving non-surgical modalities in the form of radiotherapy and concurrent chemoradiotherapy [1]. The findings of the 1991 VA larynx trial demonstrated that treating patients with advanced stage laryngeal cancer using radiotherapy and chemotherapy had comparable survival outcomes to patients treated with upfront surgery and adjuvant radiotherapy. The major advantage achieved with the induction chemotherapy and radiotherapy regimen was that 64% of patients treated non-surgically retained their larynges [2].

Source: Oral Oncology - October 21, 2017 Category: Cancer & Oncology Authors: David H. Yeh, Axel Sahovaler, Kevin Fung Source Type: research