Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) accounts for approximately 3% of all malignancies worldwide [1]. Due to a high rate of local invasion and recurrence, the overall survival rate of OSCC patients has failed to substantially rise over the last decade [2]. Especially, locally advanced OSCC remains refractory and lethal in more than 50% cases [1]. Distant metastases are rarely found on initial presentation; therefore, locoregional disease control and the elucidation of the mechanism underlying OSCC invasion are critical to improving the survival rate of OSCC patients [3].

Source: Oral Oncology - November 14, 2017 Category: Cancer & Oncology Authors: Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Tamotsu Kiyoshima, Seiji Nakamura Source Type: research