Recognition of self-DNA drives cardiac inflammation: why broken hearts fail

Nature Medicine 23, 1400 (2017). doi:10.1038/nm.4455 Authors: Kory J Lavine & Douglas L Mann Signals that govern immune cells in the heart remain poorly defined. A new report in mice shows that pathways involved in sensing viruses orchestrate monocyte and macrophage activation through recognition of DNA derived from dying cardiomyocytes following myocardial infarction.
Source: Nature Medicine - Category: General Medicine Authors: Tags: News and Views Source Type: research