Psoriasis improvement after gastric bandage in a patient partial responder to infliximab

We report a case of a psoriatic patient that experienced a dramatic improvement of psoriasis after weight loss surgery by gastric bandage. The great weight loss was accompanied by an effectiveness gain of response to infliximab. The mechanism responsible for this association is not certain, but it is probably multifactorial, involving genetic, environmental and immune‐mediated factors. It has been suggested that adipose tissue can dramatically alter the volume of drug distribution and limit drug efficacy. Moreover, a reduction of weight could favour the response to therapy and remission of the disease, inducing an improvement in patient's quality of life. Gastric bandage has a scarce rate of complications, a fast recovery and scarce life‐threatening complications. It should be considered in obese patient that not shown effectiveness to therapy.
Source: Dermatologic Therapy - Category: Dermatology Authors: Tags: THERAPEUTIC HOTLINE: SHORT PAPERS Source Type: research