Increased Insulin Resistance and Glucagon Levels in Mild/Inactive Systemic Lupus Erythematosus Patients Despite Normal Glucose Tolerance

ConclusionWe have identified that SLE patients had a bi‐hormone metabolic abnormality characterized by increased IR and hyperglucagonemia despite normal glucose tolerance and preserved beta cell function and skeletal muscle GLUT‐4 translocation. Strategies capable of ameliorating insulin sensitivity to reduce the risk of type 2 diabetes mellitus and cardiovascular disease in SLE may require more than targeting IR alone.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Facr.23237

Source: Arthritis Care and Research - December 6, 2017 Category: Rheumatology Authors: C íntia N. H. Miyake, Bruno Gualano, Wagner S. Dantas, Renato T. Pereira, William Neves, Vanessa O. Zambelli, Samuel K. Shinjo, Rosa M. Pereira, Elizabeth R. Silva, Ana Lúcia Sá‐Pinto, Eduardo Borba, Hamilton Roschel, Eloisa Bonfá, Fabiana B. Benatt Tags: Original Article Source Type: research