Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis [Original Articles]

Conclusions— According to our results, the activation of the alternative pathway of the complement system strongly contributes to serum MMP-8 concentration. Genetic polymorphism in S100A9–S100A12–S100A8 locus affects serum and plasma MMP-8 and shows a suggestive association with the risk of CVDs. Our results show that genetic variation determines a significant portion of circulating MMP-8 concentrations.

http://circgenetics.ahajournals.org/cgi/content/short/10/6/e001731?rss=1

Source: Circulation: Cardiovascular Genetics - December 6, 2017 Category: Cardiology Authors: Salminen, A., Vlachopoulou, E., Havulinna, A. S., Tervahartiala, T., Sattler, W., Lokki, M.-L., Nieminen, M. S., Perola, M., Salomaa, V., Sinisalo, J., Meri, S., Sorsa, T., Pussinen, P. J. Tags: Computational Biology, Biomarkers, Cardiovascular Disease, Genetic, Association Studies, Genetics Original Articles Source Type: research