Determination of MIC and Disk Diffusion Quality Control Guidelines for Meropenem-vaborbactam, a Novel Carbapenem/Boronic Acid β-lactamase Inhibitor Combination

Meropenem-vaborbactam is a carbapenem/cyclic boronic acid β-lactamase inhibitor combination primarily active against Gram-negative bacilli, including those harboring class A serine carbapenemases such as Klebsiella pneumoniae carbapenemase (KPC). A CLSI M23-A4 (tier-2) quality control study established broth microdilution and disk diffusion ranges for ref erence strains. Two KPC-producing K. pneumoniae ATCC strains are recommended for quality control testing.

Source: Diagnostic Microbiology and Infectious Disease - December 3, 2017 Category: Microbiology Authors: Erik Munson, Michael D. Huband, Mariana Castanheira, Kelley A. Fedler, Robert K. Flamm Source Type: research