Drug-Drug Interactions in cocaine-users and their clinical implications.

Drug-Drug Interactions in cocaine-users and their clinical implications. Curr Drug Abuse Rev. 2017 Sep 20;: Authors: Gallelli L, Gratteri S, Siniscalchi A, Cione E, Sirico S, Seminara P, De Sarro G, Cristina Caroleo M Abstract Drug-drug interactions (DDIs) are a common problem in clinical practice during drug treatments. DDIs can induce development of adverse drug reactions or reduce clinical efficacy of the drugs. In this review, using PubMed, Embase and Cochrane library we searched articles published until January 10, 2017, and described both pharmacokinetic and pharmacodynamic DDIs in cocaine consumers, focusing the interest on their clinical implications. In this review, the nodal points treated focused on: i) cocaine biochemical metabolism described for both, inactive benzoylecgonine and ecgonine methyl esters and norcocaine active metabolites. We evidenced proof of concepts deriving from rat/mice experimental studies speculating a translational approach to human in order to treat cocaine overdose. ii) Drug-drug interactions that come from clinical evidences as the case of CYP450 family enzyme inhibitors or inductors that can modulate cocaine toxicity. We highlighted the lack of knowledge concerning cocaine and CYP3A4 inhibitors (such as ketoconazole, nefazodone, erythromycin, and clarithromycin). We recorded the worst association of cocaine and beta-blockers by direct and indirect action, particularly at postsynaptic levels on ...
Source: Current Drug Abuse Reviews - Category: Addiction Tags: Curr Drug Abuse Rev Source Type: research