Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies

Publication date: Available online 1 December 2017 Source:Epilepsy & Behavior Case Reports Author(s): Patrick Kwan, Scott Mintzer, Antonio Laurenza, Anna Patten, Karen Cartwright Perampanel, a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is approved for adjunctive treatment of focal seizures, with or without secondarily generalized seizures, and for primary generalized tonic–clonic seizures in patients with epilepsy aged ≥12years. Perampanel was recently approved for monotherapy use for focal seizures in the U.S.A. Anti-seizure drug monotherapy may be preferable to polytherapy, which is generally associated with increased toxicity, non-compliance, and cost. Here, we report cases where patients had converted to perampanel monotherapy during open-label extension (OLEx) portions of 9 Phase II and III studies. Of 2245 patients who enrolled in the OLEx studies, we identified 7 patients with drug-resistant focal seizures who discontinued all non-perampanel anti-seizure drugs and were maintained on perampanel monotherapy for ≥91days until the end of data cut-off. Patients received perampanel monotherapy for up to 1099days (157weeks), most at a modal dose of 12mg. Seizure data were available for 6 patients, of whom 5 had a≥90% reduction in overall seizure frequency between baseline and their last 13-week period of monotherapy (3 were seizure-free). Perampanel monotherapy was generally well tolerate...
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research