68Ga-Galmydar: Biodistribution and Radiation Dosimetry Studies in Rodents
68Ga-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3 –1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. 68Ga-Galmydar excretes from blood pool quickly, and shows stable retention within rat myocardium in vivo for extended periods, therefore, the agent shows potential to enable myocardial perfusion imaging.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Jothilingam Sivapackiam, Richard Laforest, Vijay Sharma Source Type: research
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