Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease

In conclusion, a qualitative rather than a quantitative abnormality of the TGF-β/Smad3 pathway is involved in PKD and may be a target for disease-specific intervention.

Source: AJP: Renal Physiology - December 1, 2017 Category: Urology & Nephrology Authors: Hama, T., Nakanishi, K., Sato, M., Mukaiyama, H., Togawa, H., Shima, Y., Miyajima, M., Nozu, K., Nagao, S., Takahashi, H., Sako, M., Iijima, K., Yoshikawa, N., Suzuki, H. Tags: RESEARCH ARTICLE Source Type: research