Blockade of extracellular heat shock protein 90{alpha} by 1G6-D7 attenuates pulmonary fibrosis through inhibiting ERK signaling

In conclusion, 1G6-D7 significantly protects against BLM-induced pulmonary fibrosis by ameliorating fibroblast activation and ECM production, which may be through blocking ERK signaling. Our results suggest a safer molecular therapy, 1G6-D7, in pulmonary fibrosis.

Source: AJP: Lung Cellular and Molecular Physiology - December 1, 2017 Category: Respiratory Medicine Authors: Dong, H., Luo, L., Zou, M., Huang, C., Wan, X., Hu, Y., Le, Y., Zhao, H., Li, W., Zou, F., Cai, S. Tags: RESEARCH ARTICLE Source Type: research