Natural regulatory IgM ‐mediated autoimmune responses directed against malondialdehyde regulate oxidative and nitrosative pathways and coupled with IgM responses to nitroso‐adducts attenuate depressive and physiosomatic symptoms at the end of term pregnancy

ConclusionLowered levels of IgM responses to MDA during pregnancy are accompanied by a reduced regulation of nitro‐oxidative processes thereby explaining increased O&NS biomarkers in association with DPSS symptoms. IgM responses to NO‐adducts, which reflect nitrosylation as a consequence of increased NO production, regulate DPSS symptoms at the end of term, and are a trait marker of major depression. IgM responses to MDA are a key part of the compensatory anti‐inflammatory responses system (CIRS).

Source: Psychiatry and Clinical Neurosciences - November 1, 2017 Category: Neuroscience Authors: Chutima Roomruangwong, Decio Sabbatini Barbosa, Carine Coneglian de Farias, Andressa Keiko Matsumoto, Thiago Hissnauer Leal Baltus, Nayara Rampazzo Morelli, Buranee Kanchanatawan, Sebastien Duleu, Michel Geffard, Michael Maes Tags: Regular Article Source Type: research