Advanced glycation end ‐products increase IL‐6 and ICAM‐1 expression via RAGE, MAPK and NF‐κB pathways in human gingival fibroblasts

ConclusionAGEs increase IL‐6 and ICAM‐1 expression via the RAGE, MAPK and NF‐κB pathways in HGFs and may exacerbate the progression of the pathogenesis of periodontal diseases.

Source: Journal of Periodontal Research - November 30, 2017 Category: Dentistry Authors: K. Nonaka, Y. Kajiura, M. Bando, E. Sakamoto, Y. Inagaki, J. H. Lew, K. Naruishi, T. Ikuta, K. Yoshida, T. Kobayashi, H. Yoshie, T. Nagata, J. Kido Tags: ORIGINAL ARTICLE Source Type: research