Symptom recovery and relationship to structure of corpus callosum in individuals with an ‘at risk mental state’

The corpus callosum (CC), which connects homologous frontal areas involved in cognitive functions associated with executive functions relevant to schizophrenia (de Lacoste, 1985; David, 1994; Pantelis et al., 1997; Crow 1998), has been implicated in schizophrenia, with evidence of structural abnormalities observed across the various stages of illness (Walterfang et al., 2008a; Whitford et al., 2011). Recently, many studies have revealed that an increase in the severity of psychotic symptoms or deficits in cognitive functions are associated with progressive changes in the CC (Koutsouleris et al., 2010; Bleich-Cohen et al., 2012; Whitford et al., 2015; Walterfang et al., 2008).

Source: Psychiatry Research: Neuroimaging - November 29, 2017 Category: Psychiatry Authors: Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno Source Type: research