Biological consequences of improving the structural stability of hairpins that have antimicrobial activity

This study shows that rational design can be applied to improve the structural stability of beta‐hairpin antimicrobial peptides. Exploring the relationship between structure and activity, however, shows that antimicrobial peptide activity does not always correlate with structural stability. There is also significant evidence that structural optimization can have opposite effects on gram‐positive and gram‐negative bacteria.
Source: Journal of Peptide Science - Category: Biochemistry Authors: Tags: Research Article Source Type: research