Subcortical Volumetric Differences Between Clinical Stages of Young People with Affective and Psychotic Disorders

The aim of this study was to investigate differences in subcortical and hippocampal volumes between healthy controls, young people at an early stage of affective and psychotic disorders and those in more advanced stages, to identify markers associated with functional outcomes and illness severity. Young people presenting to youth mental health services with admixtures of depressive, manic and psychotic symptoms (n = 141), and healthy counterparts (n = 49), aged 18 –25 were recruited. Participants underwent magnetic resonance imaging, clinical assessments and were rated as to their current clinical stage.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research