Alpha ‐defensins (α‐Defs) in Crohn's disease: Decrease of ileal α‐Def 5 via permanent methylation and increase in plasma α‐Def 1‐3 concentrations offering biomarker utility

Conclusions: Plasma α‐Defs 1‐3 concentrations correlate with the degree of inflammation and appear to be specific biomarkers of ileal‐CD at diagnosis. Ileal α‐Def 5 expression is permanently downregulated by methylation. This article is protected by copyright. All rights reserved.

Source: Clinical and Experimental Immunology - November 28, 2017 Category: Allergy & Immunology Authors: Elena Cerrillo, In és Moret, Marisa Iborra, David Ramos, Enrique Busó, Luis Tortosa, Esteban Sáez‐González, Pilar Nos, Belén Beltrán Tags: Original Article Source Type: research