MUC1 ‐ and survivin‐based DNA vaccine combining immunoadjuvants CpG and interleukin 2 in a bicistronic expression plasmid generates specific immune responses and anti‐tumor effects in a murine colorectal carcinoma model

In conclusion, the DNA vaccine containing a CpG motif in bicistronic form showed good effects on colorectal cancer by inhibiting both tumor growth and metastasis, and combination with oxaliplatin could improve its anti‐tumor effects.
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Source: Scandinavian Journal of Immunology - November 28, 2017 Category: Allergy & Immunology Authors: Chenlu Liu, Yu Xie, Bo Sun, Fei Geng, Fangfang Zhang, Qianqian Guo, Hui Wu, Bin Yu, Jiaxin Wu, Xianghui Yu, Wei Kong, Haihong Zhang Tags: Regular Article Source Type: research