Liver ‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis

AngewchemLiver ‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis: Targeting of the human ribosome is an unprecedented therapeutic modality with a genome ‐wide selectivity challenge. A liver‐targeted drug candidate is described that inhibits ribosomal synthesis of PCSK9,...

Source: Organometallic Current - November 28, 2017 Category: Chemistry Tags: Drug discovery Source Type: blogs