Nucleophilic Arylation of N,O ‐Ketene Acetals with Triaryl Aluminum Reagents: Access to α‐Aryl Amides through an Umpolung Process

AngewchemNucleophilic Arylation of N,O ‐Ketene Acetals with Triaryl Aluminum Reagents: Access to α‐Aryl Amides through an Umpolung Process: A novel approach for the umpolung α‐arylation of amides is presented. By the nucleophilic phenylation of O‐silyl N,O‐ketene acetals, generated in situ from N‐alkoxy amides, a phenyl group can be introduced...

Source: Organometallic Current - November 28, 2017 Category: Chemistry Tags: Umpolung Source Type: blogs