BCL ‐XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression

We report the interaction of BCL‐XL with RASSF6. BCL‐XL inhibits the interaction between RASSF6 and MDM2 and suppresses p53 expression. Consequently, BCL‐XL antagonizes RASSF6‐mediated apoptosis. Thus, the inhibition of RASSF6‐mediated apoptosis also underlies the prosurvival role of BCL‐XL.

RASSF6 blocks MDM2‐mediated p53 degradation and induces apoptosis. BCL‐XL inhibits the interaction between RASSF6 and MDM2 and plays a prosurvival role.

Source: Genes to Cells - November 1, 2017 Category: Genetics & Stem Cells Authors: Xiaoyin Xu, Hiroaki Iwasa, Shakhawoat Hossain, Aradhan Sarkar, Junichi Maruyama, Kyoko Arimoto ‐Matsuzaki, Yutaka Hata Tags: ORIGINAL ARTICLE Source Type: research