Tau-based therapies in neurodegeneration: opportunities and challenges

Nature Reviews Drug Discovery 16, 863 (2017). doi:10.1038/nrd.2017.155 Authors: Chuanzhou Li & Jürgen Götz Aggregates of the microtubule-associated protein tau are a defining feature of several neurodegenerative diseases that are collectively known as tauopathies, and constitute one of the hallmark lesions of Alzheimer disease (AD). Given the lack of efficacy to date of amyloid-β-targeted therapies for AD, interest is
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research