Expanding LogP: Present Possibilities

Due to the high candidate exclusion rate during a drug development process, an early prediction of the pharmacokinetic behavior would be needed. Accordingly, high performance bioaffinity chromatography (HPBAC) approaches are growing in popularity, however, there is a lack of knowledge and no consensus about the relation between HPBAC measurements, in vivo distribution and blood brain barrier (BBB) penetration behavior. With respect to radiotracers, there is almost no reference data available for plasma protein binding (PPB), permeability (Pm) and the membrane coefficient (KIAM).

Source: Nuclear Medicine and Biology - November 27, 2017 Category: Nuclear Medicine Authors: Chrysoula Vraka, Sanja Mijailovic, Vanessa Fr öhlich, Markus Zeilinger, Eva-Maria Klebermass, Wolfgang Wadsak, Karl-Heinz Wagner, Marcus Hacker, Markus Mitterhauser Source Type: research