Morphometric study of adipocytes on breast cancer by means of photonic microscopy and image analysis
Abstract
Worldwide, breast cancer (BrCa) is currently the leading cause of deaths associated to malignant lesions in adult women. Given that some studies have mentioned that peritumoral adipocytes may contribute to breast carcinogenesis, present work sought to quantitative evaluate the morphometry of these cells in a group of adult women. Three thousand six hundred sixty four breast adipocytes, that came from biopsies of a group of adult females with different types of breast carcinomas (ductal, lobular, and mixed) and one with normal tissues, were evaluated through an image analysis (IA) process regarding six morphometric descriptors: area (A), perimeter (P), Feret diameter (FD), aspect ratio (AR), roundness factor (RF), and fractal dimension of cellular contour (FDC). Data showed that the adipocytes of the normal tissues group were bigger (A: 3398 ± 2331 µm2, P: 239 ± 83 µm, and FD: 79.9 ± 24.5 µm) than those from BrCa samples (A: 2860 ± 1933 µm2, P: 214 ± 66 µm, and FD: 73.2 ± 22.5 µm), and presented a more irregular contour (FDC of 1.370 ± 0.037 for normal group and of 1.335 ± 0.049 for the oncologic one). Moreover, it could be accounted that adipocytes of mixed carcinomas were largest (FD: 75.1 ± 22.4 µm) than those of lobular lesions (FD: 61.6 ± 22.6 µm), while the adipocytes of ductal carcinomas were the most oval (AR: 1.421 ± 0.524) and roughest (FDC: 1.324 ± 0.050) cells. IA results suggest that BrCa...
Source: Microscopy Research and Technique - Category: Laboratory Medicine Authors: Luis Eduardo Su árez–Nájera, José Jorge Chanona–Pérez, Alejandra Valdivia–Flores, Daniel Marrero–Rodríguez, Mauricio Salcedo–Vargas, David Israel García–Ruiz, Marco Antonio Castro– Reyes Tags: RESEARCH ARTICLE Source Type: research
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