Boron–18F containing positron emission tomography radiotracers: advances and opportunities

Standard [18F]fluorination methods to form carbon–fluorine bonds can have some limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the formation of boron–[18F]fluorine bonds and have the potential to give high specific activities at room temperature forming a bond that is stable in vivo. There is considerable potential in future applications, particularly in relation to multimodal imaging and the provision of rapid efficient labelling protocols. Copyright © 2014 John Wiley & Sons, Ltd.
Standard [18F]fluorination methods to form carbon–fluorine bonds have many limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the formation of boron–[18F]fluorine bonds and have the potential to give high specific activities at room temperature, forming a bond that is stable in vivo. There is considerable potential for future applications of such compounds, particularly in relation to multimodal imaging and the provision of rapid efficient radiolabelling protocols.

Source: Contrast Media and Molecular Imaging - August 7, 2014 Category: Radiology Authors: Benjamin P. Burke, Gonçalo S. Clemente, Stephen J. Archibald Tags: Review Source Type: research