Non ictal onset zone: A window to ictal dynamics

Publication date: 2017 Source:Epilepsy & Behavior Case Reports, Volume 8 Author(s): Pegah Afra, Sara J. Hanrahan, Spencer Sterling Kellis, Paul House The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus (MTG). We compare action-potential (AP) and local field potentials (LFP) recorded from MEA with ECoG. Seizure onset in the mesial-temporal lobe was characterized by changes in the pattern of AP-firing without clear changes in LFP or ECoG in MTG. This suggests simultaneous analysis of neuronal activity in differing spatial scales and frequency ranges provide complementary insights into how focal and network neurophysiological activity contribute to ictal activity.

Source: Epilepsy and Behavior Case Reports - November 27, 2017 Category: Neurology Source Type: research