Autologous matrix induced Chondrogenesis and generational development of autologous chondrocyte implantation

The treatment of osteochondral defects of the talus is still controversial. Matrix guided treatment options for covering of the defect with a scaffold have gained increasing popularity. Cellular-based Autologous Chondrocyte Implantation (ACI) has undergone a generational development overcoming the surgical drawbacks related to the use of the periosteal flap over time. Since ACI is associated with high costs and limited in availability, Autologous Matrix Induced Chondrogenesis (AMIC), a single- step procedure combining microfracturing of the subchondral bone to release bone marrow mesenchymal stem cells in combination with the coverage of an acellular matrix, has gained increasing popularity.
Source: Operative Techniques in Orthopaedics - Category: Orthopaedics Authors: Source Type: research