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Ligand-accelerated non-directed C –H functionalization of arenes Nature551,489–493 (23 November 2017)doi:10.1038/nature24632 Peng Wang, Pritha Verma, Guoqin Xia, Jun Shi, Jennifer X. Qiao+ et al.Using a ligand as a promoter enhances the reactivity of the palladium catalyst in non-directed C –H functionalization of arenes, enabling the arene to be used as the limiting reagent.The directed activation of carbon –hydrogen bonds (C–H) is important in the development of synthetically useful reactions, owing to the proximity-induced reactivity and selectivity that is enabled by coordinating functional groups. Palladium-catalysed non-directed C–H activation could potentially enable further useful rea ctions, because it can reach more distant sites and be applied to substrates that do not contain appropriate directing groups; however, its development has faced substantial challenges associated with the lack of sufficiently active palladium catalysts. Currently used palladium catalysts are rea ctive only with electron-rich arenes, unless an excess of arene is used, which limits synthetic applications.

Source: Organometallic Current - November 23, 2017 Category: Chemistry Tags: C-H Functionalization Pd Catalyzed Source Type: blogs